Mohamed Khattab, MD

Dr. Khattab completed medical school at the Johns Hopkins School of Medicine. He initially trained in neurosurgery at NYU. After becoming intrigued by recent advances in radiotherapy and radiosurgery – and how it can be used to treat cancers as well as benign conditions – he transferred to radiation oncology residency at Vanderbilt. He was selected to serve as Chief Resident during his final year at Vanderbilt. Dr. Khattab has over 35 publications in prestigious journals, has been invited to give lectures nationally and internationally, and has been asked to share his expertise with industry leaders as a consultant.

As a radiation oncologist, Dr. Khattab primarily focuses on treatment of patients with all types of malignancies including breast, prostate, lung and gastrointestinal cancers and brain tumors. Dr. Khattab has numerous publications pertaining to treatment of patients with these cancers. He uses the most advanced techniques including VMAT, IMRT, IGRT, Stereotactic Radiosurgery (SRS), stereotactic ablative/body radiotherapy (SABR/SBRT), and brachytherapy.

Dr. Khattab also has a special expertise in treating benign diseases. He has used his unique background in radiation oncology and neurosurgery to pioneer novel noninvasive treatments expanding the use of “functional radiosurgery” for benign conditions such as treatment-resistant major depression, obsessive-compulsive disorder, essential tremor, parkinsonian tremor, trigeminal neuralgia, chronic pain, and mesial temporal lobe epilepsy. In fact, Dr. Khattab and his collaborators were first in the world to treat some of these conditions, such as major depression, OCD, and tremor, with a frameless and incisionless approach. Healthcare leaders have sought Dr. Khattab’s expertise in the management of these diseases using radiosurgery. Dr. Khattab also has a special interest and has published and lectured extensively on stereotactic radiosurgery for treatment of vestibular schwannomas (acoustic neuromas), arteriovenous malformations (AVMs), pituitary tumors, meningiomas, and paragangliomas. Dr. Khattab has Gamma Knife Perfexion/ICON training and certification and also uses frameless linac-based radiosurgery.

Learn more about what to expect from radiation treatment.

Personal

When he’s not treating patients, Dr. Khattab enjoys quality time with his friends and family, hiking, live music, travel and learning foreign languages. He speaks Arabic and English fluently, and has studied Spanish, German and Portuguese. He loves how languages allow him to connect with people from all over the world and to experience their unique cultures more in depth.

Leadership and Recognition

VUMC Chief Resident in Radiation Oncology, 2020-2021

VUMC Radiation Oncology Quality Assurance & Safety Committee Resident Representative, 2020-2021

Executive Board Member, Johns Hopkins SOM chapter of the American Medical Association, 2013-2014

Cornell Tradition Fellow, 2005-2008

The Andrew Watson Sellards Scholarship

The Johns Hopkins Presidential Scholarship

Baltimore City Medical Society Foundation Award

Owsei Temkin Scholarship

Dufer Scholarship

Sprague Scholarship

The Lester Persky Research Award and Fellowship

Johns Hopkins SOM Dean’s Summer Research Award

Magna Cum Laude, Cornell University

Cornell Tradition Fellow

Flemington Eye and Refractive Surgery Scholarship

Paul Phillips Scholarship

Flemington Rotary Scholarship

Rebmann and Calloway Scholarship

Trenton Times All-Star Academics Finalist

Professional Memberships

American Society for Radiation Oncology (ASTRO)

Radiological Society of North America (RSNA)

Congress of Neurological Surgeons

Research

Dr. Khattab has conducted research at the Johns Hopkins School of Medicine, Harvard Medical School, Vanderbilt University Medical Center and Cornell University. He has served as principal investigator on multiple funded clinical trials. He has published book chapters, over 35 peer-reviewed publications, and has helped draft American Medical Association legislation. He has published in journals including the Proceedings of the National Academy of Sciences, International Journal of Radiation Oncology – Biology – Physics, Prostate, Otology & Neurotology, Neurosurgery, Otolaryngolgy- Head & Neck Surgery, Global Spine Journal, Brachytherapy and others.

Publications

Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci USA. March 2012.

Elder BD, Goodwin CR, Jusue-Torres I, Sankey EW, Khattab MH, Rigamonti D. Outcomes and Experience with Lumbopleural Shunts in the Management of Idiopathic Intracranial Hypertension. World Neurosurgery. August 2015.

Sankey EW*, Khattab MH*, Elder BD, Goodwin CR, Rekate HL, Rigamonti D. Lumboatrial Shunt in a Patient with Crouzon Syndrome Complicated by Pseudotumor Cerebri. Journal of Clinical Neuroscience. September 2015. *Co-first author.

Khattab MH, Marciscano AE, Lo SS, Lim M, Laterra JJ, Kleinberg LR, Redmond KJ. Anti-angiogenic Therapies and Extracranial Metastasis in Glioblastoma: A case report and review of the literature. Case Reports in Oncological Medicine. June 2015.

Goodwin CR, Atman D, Khattab MH, Elder BD, Kosztowski TA, Rhee J, Hughes C, Bydon A, Wolinsky J. Cervical Fusion for Congenital Pedicle Syndrome Presenting with Myelopathy. World Neurosurg. September 2015.

Mian OY*, Khattab MH*, Abubaker-Sharif B, Hedayati M, Kirchner J, Coulter J, Isaacs JT, DeWeese TL. Loss of GSTP1 Leads to Accumulation of Oxidative Base Damage and Promotes Cell Survival Following Ionizing Radiation of LNCaP Cells. Prostate. October 2015. *Co-first author.

Goodwin CR*, Khattab MH*, Crane G, Sankey EW, McCarthy E, Sciubba D. Epithelial-Myoepithelial Carcinoma Metastasis to the Thoracic Spine. Journal of Clinical Neuroscience. October 2015. *Co-first author.

Goodwin CR, Khattab MH, Sankey EW, Elder BD, Kosztowski TA, Sarabia-Estrada R, Bydon A, Witham TF, Wolinsky J, Gokaslan ZL, Sciubba DM. Factors Associated with Life Expectancy in Patients with Metastatic Spine Disease from Adenocarcinoma of the Lung. Global Spine Journal. October 2015.

Marciscano AE, Huang J, Tamargo RJ, Hu C, Khattab MH, Aggrawal S, Lim M, Redmond KJ, Rigamonti D, Kleinberg LR.Long-term Outcomes with Planned Multi-stage Reduced Dose Repeat Stereotactic Radiosurgery for Treatment of Inoperable High-Grade Arteriovenous Malformations: An Observational Retrospective Cohort Study. Neurosurgery. July 2017.

Hedayati M, Abubaker-Sharif B, Khattab M, Razavi A, Mohammed I, Nejad A, Wabler M, Zhou H, Mihalic J, Gruettner C, DeWeese TL, Ivkov R. An optimized spectrophotometric assay for convenient and accurate quantitation of intracellular iron from iron oxide nanoparticles. International Journal of Hyperthermia. June 2018.

Fenlon JB*, Khattab MH*, Ferguson DC, Luo G, Chambless LB, Kirschner AN. Linear Accelerator Based Stereotactic Radiosurgery for Cranial, Intraparenchymal Metastasis of a Malignant Peripheral Nerve Sheath Tumor: Case Report and Review of the Literature. World Neurosurgery. March 2019. *Co-first author.

Khattab MH, Sherry AD, Ahlers CG, Kirschner AN. Radiation-associated epithelial myoepithelial carcinoma among five secondary malignancies: A case report and review of literature. World J Clin Oncol. December 2018.

Khattab MH, Sherry AD, Whitaker R, Wharton DM, Weaver KD, Chambless LB, Cmelak AJ ,Attia A. Stereotactic Radiosurgery for Vestibular Schwannoma: Longitudinal Audiologic Assessment in Single and Fractionated Treatments. Neurosurgery. December 2019.

Khattab MH, Newman NB, Wharton DM, Sherry AD, Luo G, Manzoor NF, Rivas A, Davis LT, Chambless LB, Attia A, Cmelak AJ. Longitudinal Radiographic Outcomes of Vestibular Schwannoma in Single and Fractionated Stereotactic Radiosurgery: A Retrospective Cohort Study. Journal of Neurological Surgery Part B: Skull Base. June 2020.

Khattab MH, Sherry AD, Kim E, Anderson JL, Luo G, Yu H, Cmelak AJ, Englot DJ, Chambless LB, Attia A. Body Mass Index and Response to Stereotactic Radiosurgery in the Treatment of Refractory Trigeminal Neuralgia. J Radiosurgery & SBRT. 2020.

Khattab MH, Sherry AD, Cmelak AJ, Attia A. In Reply: A Retrospective Cohort Study of Longitudinal Audiologic Assessment in Single and Fractionated Stereotactic Radiosurgery for Vestibular Schwannoma. Neurosurgery. December 2019.

Sherry AD, Khattab MH, Totten D, Wharton DM, Luo G, Manzoor NF, Rivas A, Chambless LB, Davis LT, Attia A, Cmelak AJ. Current Volumetric Models Overestimate Vestibular Schwannoma Size Following Stereotactic Radiosurgery. Otology & Neurotology. February 2020.

Anderson JL, Khattab MH, Anderson C, Sherry AD, Luo G, Manzoor N, Attia A, Netterville J, Cmelak AJ. Long-term Outcomes for the Treatment of Paragangliomas in the Upfront, Adjuvant and Salvage Settings with Stereotactic Radiosurgery and Intensity Modulated Radiotherapy. Otology & Neurotology. January 2020.

Sherry AD, Khattab MH, Xu MC, Kelly P, Anderson JL, Luo G, Utz AL, Chambless LB, Cmelak AJ, Attia A. Outcomes of Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy for Refractory Cushing’s Disease. Pituitary. December 2019.

Totten DJ, Manzoor NF, Sherry AD, Khattab MH, Link MJ, Cmelak AJ, Haynes DS, Rivas A, Carlson ML, Attia A. Radiotherapy and Radiosurgery for Treatment of Residual or Recurrent Endolymphatic Sac Tumor
Following Prior Microsurgical Resection. Otology & Neurotology. July 2020.

Sherry AD, Bezzerides M, Khattab MH, Luo G, Ancell KK, Kirschner AN. An Autoimmune-Based, Paraneoplastic Neurologic Syndrome Following Checkpoint Inhibiton and Concurrent Radiotherapy for
Merkel Cell: Case Report. Strahlentherapie und Onkologie. July 2020.

Sherry AD, Khattab MH, Xu MC, Kelly P, Anderson JL, Luo G, Utz AL, Chambless LB, Cmelak AJ, Attia A. Long-Term Outcomes of Hypofractionated Stereotactic Radiotherapy for Refractory Functional Pituitary Adenoma. Journal of Radiation Oncology. July 2021.

Khattab MH*, Sherry AD*, Xu MC, Kelly P, Anderson JL, Luo G, Chambless LB, Cmelak AJ, Attia A. Stereotactic Radiosurgery and Hypofractionated Stereotactic Radiotherapy for Nonfunctioning Pituitary Adenoma. *Co-first author. Journal of Neurological Surgery Part B: Skull Base. July 2021.

Khattab MH, Sherry AD, Manzoor N, Totten DJ, Luo G, Chambless LB, Rivas A, Haynes DS, Cmelak AJ, Attia A. Progressive Vestibular Schwannoma Following Subtotal or Near-Total Resection: Dose-Escalated Versus Standard-Dose Salvage Stereotactic Radiosurgery. Journal of Neurological Surgery Part B: Skull Base.
July 2021.

Anderson JL, Khattab MH, Sherry AD, Luo G, Chitale RV, Froehler MT, Fusco MR, Cmelak AJ, Attia A. Improved Cerebral Arteriovenous Malformation Obliteration with 3D Rotational Digital Subtraction Angiography for Radiosurgical Planning. Neurosurgery. December 2020.

Khattab MH, Sherry AD, Freeman ML, Luo G, Osmundson EC, Attia A, Cmelak AJ. Recommendations for Radiosurgery and Stereotactic Ablative Radiotherapy Terminology to Guide Clinical and Research Practices for the Medical Oncologist, Radiation Oncologist and Surgeon. Journal of Radiation Oncology. May 2020.

Manzoor NF, Yancey KL, Aulino JM, Sherry AD, Khattab MH, Cmelak AJ, Morrel WG, Haynes DS, Bennett ML, O’Malley MR, Netterville J, Wanna G, Rivas A. Contemporary Management of Jugular Paragangliomas with Neural Preservation. Otolaryngology – Head & Neck Surgery. February 2021.

Manzoor NF, Khattab MH, Sherry AD, Perkins EL, Attia A, Cmelak AJ, Haynes DS, Rivas A. Transient Subacute Facial Nerve Dysfunction after Dual Modality Treatment of Large Vestibular Schwannomas. Otology & Neurotology. February 2021.

Khattab MH*, Sherry AD*, Aulino JM, Becker JE, Petrie WM, Cmelak AJ: Chronic Electroconvulsive Therapy Can Induce Calvarial Hyperemia and Marrow Replacement. *Co-first author. Journal of ECT. June 2021.

Khattab MH, Sherry AD, Jessop AC, Ciombor KK, Chakrvarthy B. Early Detection of SARS-CoV-2 from Staging PET-CT. Journal of Radiation Oncology. September 2020.

Khattab MH, Sherry AD, Barker C. The Birth, Decline, and Contemporary Re-emergence of Endovascular Brachytherapy for the Prevention of In-Stent Restenosis. Brachytherapy. March-April 2021.

Totten DJ, Sherry AD, Manzoor NF, Perkins EL, Cass ND, Khattab MH, Cmelak AJ, Haynes DS, Aulino JM. Diameter-Based Volumetric Models May Inadequately Calculate Jugular Paraganglioma Volume Following Sub-Total Resection. Otology & Neurotology. June 2021.

Xu MC, Khattab MH, Luo G, Sherry AD, Morales-Paliza M, Chaballout BH, Anderson JL , Attia A, Cmelak AJ. Effects of Conveversus Multi-leaf Collimation on Dosimetry and Neurotoxicity in Patients with Arteriovenous Malformation Treated by Stereotactic Radiosurgery. Journal of Radiosurgery & SBRT. In press.

Manzoor NF, Nassiri AM, Sherry AD, Dang S, Yancey KL, Mansour M, Perkins EL, Khattab MH, Thompson RC, O’Malley MR, Bennett ML, Rivas AC, Haynes DS. Predictors of Recurrence after Sub-total or Near-total Resection of Vestibular Schwannoma: Importance of Tumor Volume and Ventral Extension. In press.

Khattab MH, Cmelak AJ, Sherry AD, Luo G, Wang L,Yu H, Hedera P, Phibbs FT, Lindsell CJ, Neimat J, Kirschner AN. Noninvasive Thalamotomy for Refractory Tremor by Frameless Radiosurgery. Int J Radiat Oncol Biol. August 2021.