Home > Our Doctors > Paul W. Sperduto, MD, MPP, FASTRO

Paul W. Sperduto, MD, MPP, FASTRO

Board Certification

Radiation Oncology


National Institute of Health (NIH); National Cancer Institute (NCI), Radiation Oncology


Duke University Medical Center, Durham, NC, Internal Medicine

Medical School

Duke University School of Medicine, Durham, NC

Graduate School

Duke University School of Public Policy, Durham, NC, MPP

Undergraduate College

Duke University, Durham, NC, B.A.

Watch Dr. Sperduto’s interview on WCCO 4 News at Noon Show.

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I consider it an honor and privilege to care for my patients in times of greatest need.  The part of my career that I cherish the most is the close relationship, the patient-doctor relationship that my team and I develop with the patients while treating cancer.  I do everything I can to make the often challenging process crystal clear and less frightening.

Dr. Sperduto is the Director of Minneapolis Radiation Oncology at MRO Ridgeview Regional Therapy Center in Waconia. He joined MRO in 1993.

His clinical practice focuses on using radiation therapy for a wide range of cancers, with a particular interest in brain tumors. Dr. Sperduto is nationally recognized for his leadership in the advancement of radiation oncology technology and treatment protocols, including Gamma Knife Radiosurgery.

He also generously shares his time for international humanitarian benefits. Dr. Sperduto has worked as a volunteer physician, teacher, or consultant in programs for the poor of the United States as well as in China, India, Taiwan, and the United Kingdom.

Dr. Sperduto enjoys playing tennis, traveling and spending time with his family.

Learn more about what to expect from radiation treatment.

Leadership and Recognition

Co-Editor, Textbook of Radiation Oncology Treatment Planning

Director of Radiation Oncology at Ridgeview Medical Center and member of Ridgeview’s Cancer Care Committee

Co-director of the Gamma Knife Center at the University of Minnesota

Co-chair and past president of X-Knife Society (Radiosurgery) and principal investigator of the Radiation Therapy Oncology Group

Fellow of the American Society for Radiation Oncology (ASTRO)

Humphrey Fellow at the Humphrey Institute of Public Affairs

Henry Luce Scholarship for “15 Future Leaders of America”

American Cancer Society Lane Adams Award for Excellence in Caring and Promoting Improved Quality of Life for Persons with Cancer

2002 Society of Neuro-Oncology Award for Excellence in Clinical Research

Advisor to the Pentagon on the Medical Free Electron Laser Program

American Society of Radiation Oncology, Best of ASTRO Award for Research, multiple years

Metro-Minnesota CCOP, Award for Distinction in Clinical Research

Society of NeuroOncology (SNO), Award for Excellence in Clinical Research

Duke School of Medicine, Jones and Guerrero Scholarship for Research

Minnesota Monthly, 2018 Top DoctorsRadiation Oncology

Mpls.St.Paul Top Doctor, 2007, 2009, 2010, 2011, 2016, 2017, 2018Radiation Oncology

US News & World Report, Best Doctors in MinnesotaRadiation Oncology

Professional Memberships

Fellow, American Society for Radiation Oncology (ASTRO); Plenary Speaker at ASTRO annual meeting


Principal Investigator: four international NIH-approved research studies/clinical trials investigating better ways to treat brain tumors. 


Dr. Sperduto is the author of more than 60 peer-reviewed articles published in medical journals, 10 textbook chapters and is the co-editor of the textbook, Treatment Planning in Radiation Oncology.

Visit PubMed for a listing of Dr. Sperduto’s journal articles.

PubMed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.